Prof. Izhak Michaelevski

  • Research Questions

    • What is the role of ABL and AKT protein kinases in synaptic transmission and plasticity & memory formation?

    • How protein phosphorylation affects memory engram related gene expression?

    • What is the mechanism of Alzheimer’s disease related amyloid beta peptide effect on synaptic activity/plasticity?

    • How electromagnetic radiation may affect protein aggregation in neurodegenerative diseases? – in collaboration with the NITR (Dr. I. Koman, head)

    • How interplay aging-related cognitive impairments and depression? – in collaboration with Prof. A. Pinhasov

    • How can neurodegenerative diseases be diagnosed by synaptic pathology identification high-throughput approach? – in collaboration with Dr. E. Perlson

    • Can be neural coding/information processing quantum based?

    • Is spatial mapping of memory the major role of hippocampus?

  • Methodologies used

    • Electrophysiology: patch clamp in cell cultures and slices, field recording ex vivo and in vivo in anesthesized and freely moving animals, LFP, EEG

    • Optical Imaging

    • Optogenetics

    • Behavioral Neuroscience

    • High-throughput methods: mass-spectrometry, proteomics, transcriptomics, bioinformatics

    • Biochemical methods

    • Theoretical Neuroscience and Biophysics

  • Keywords

    • ​Synaptic transmission, synaptic plasticity, signal transduction, learning and memory, neural network, information coding, neurodegenerative diseases, protein kinases

  • Courses for Advanced Neuroscience Study

    • Biophysics of Excitable Tissue

    • Synaptic Transmission and Plasticity

    • Molecular and Functional Mechanisms of Learning and Memory

    • Molecular Mechanisms of Neurodegenerative Diseases

    • Neuropharmacology

  • Chairman, The Integrative Brain Science Center – Ariel (IBSCA)

  • Coordinator, Advanced Neuroscience Study Program

  • Head, Laboratory of Molecular & Functional Neurobiology

Phone: +972-3-614-3068

Website: http://www.brainresearchhub.net

Email: izhakmi@ariel.ac.il

© 2018 Integrative Brain Science Center - Ariel (IBSCA), Ariel University, Ariel 4070000, Israel

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